Differential effect of whisker trimming on excitatory and inhibitory transmission in primary somatosensory cortex of the adult rat in vivo.

The effects of sensory deprivation on excitatory and inhibitory activity in the primary somatosensory cortex were studied in the adult rat. Excitatory and inhibitory transmission generated by whisker stimulation, and neuronal responsiveness to iontophoretically applied excitatory amino acids were recorded. Whisker input deprivation, through whisker trimming for a median of 24 days, resulted in a significant decrease in excitatory transmission to surround whisker stimulation. In contrast, the response magnitude to principal whisker stimulation remained unchanged. However, the response latencies to principal whisker and surround whisker stimulation were significantly reduced, which led to altered temporal response distributions in deprived cells. Neurons deprived of sensory input were significantly less responsive to glutamate, N-methyl-D-aspartate, alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate and kainate. Following deprivation, no change was observed in cortical inhibitory transmission measured 30-200 ms post-stimulus. These results show that excitatory transmission (including excitatory amino acid receptor function) is altered by adult whisker deprivation.